منابع مشابه
Anabolic Therapies
The striking clinical benefits of intermittent parathyroid hormone in osteoporosis have begun a new era of skeletal anabolic agents. Recombinant human parathyroid hormone (rhPTH) (1-34) is the first US Food and Drug Administration-approved anabolic therapy. Its use has been limited by the need for subcutaneous injection. Newer delivery systems include transdermal and oral preparations. Newer an...
متن کاملA review of anabolic therapies for osteoporosis
Osteoporosis results from a loss of bone mass and bone structure such that the bone becomes weak and fractures with very little trauma. Until recently, the approved osteoporosis therapies prevented more bone loss by altering osteoclast activity and lifespan. Recently, attention has turned away from osteoclast inhibition to agents that can stimulate the osteoblast to form new bone, or anabolic a...
متن کاملMechanisms involved in skeletal anabolic therapies.
Since parathyroid hormone (PTH) is the only proven anabolic therapy for bone, it becomes the benchmark by which new treatments will be evaluated. The anabolic effect of PTH is dependent upon intermittent administration, but when an elevated PTH level is maintained even for a few hours it initiates processes leading to new osteoclast formation, and the consequent resorption overrides the effects...
متن کاملBone Biology and Anabolic Therapies for Bone: Current Status and Future Prospects
Bone is continuously remodelled at many sites asynchronously throughout the skeleton, with bone formation and resorption balanced at these sites to retain bone structure. Negative balance resulting in bone loss and osteoporosis, with consequent fractures, has mainly been prevented or treated by anti-resorptive drugs that inhibit osteoclast formation and/or activity, with new prospects now of an...
متن کاملAnabolic steroids.
Athletes, like others, use recreational and lorillicit psychoactive drugs. However, many athletes also use drugs to enhance their training or performance, including an array of bizarre and exotic substances. Although the majority of these substances are not psychoactive, they may be abused by athletes. Some of these substances, such as anabolic steroids and human growth honnone, are referred to...
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ژورنال
عنوان ژورنال: Current Osteoporosis Reports
سال: 2010
ISSN: 1544-1873,1544-2241
DOI: 10.1007/s11914-010-0005-4